Table 1 List of tau modifications identified from human AD brains.

From: An HDAC6-dependent surveillance mechanism suppresses tau-mediated neurodegeneration and cognitive decline

PTM-Residue

Peptide

(−10logp)

ppm

p-S46

45ESPLQTPTEDGSEEPGSETSDAK67

15.13

1.0

p-T50

45ESPLQTPTEDGSEEPGSETSDAK67

43.49

−1.2

p-T175

171IPAKTPPAPK180

53.71

−0.3

p-T181

175TPPAPKTPPSSGEPPK190

60.80

−0.6

p-S184

175TPPAPKTPPSSGEPPK180

21.79

−3.1

p-S198

195SGYSSPGSPGTPGSR209

53.54

0.2

p-S199

195SGYSSPGSPGTPGSR209

53.91

−1.1

p-S202

195SGYSSPGSPGTPGSR209

44.83

0.1

p-S210

210SRTPSLPTPPTR221

19.07

0.2

p-T212

212TPSLPTPPTREPK224

34.30

−0.3

p-S214

210SRTPSLPTPPTR221

52.35

−0.5

p-T217

212TPSLPTPPTREPK224

42.92

0.4

p-T231

226VAVVRTPPKSPSSAK240

40.57

0.7

p-S235

225KVAVVRTPPKSPSSAK240

28.16

0.1

p-S237

226VAVVRTPPKSPSSAK240

43.63

0.3

p-S238

226VAVVRTPPKSPSSAK240

34.65

0.2

ac-K259

258SKIGSTENLK267

15.79

−0.1

p-S262

260IGSTENLKHQPGGGK274

29.82

−0.5

ac-K311

306VQIVYKPVDLSK317

39.04

0.0

ac-K385

384AKTDHGAEIVYK395

46.13

0.6

p-S396

386TDHGAEIVYKSPVVSGDTSPR406

48.12

0.0

p-T403

386TDHGAEIVYKSPVVSGDTSPR406

54.50

0.1

p-S404

396SPVVSGDTSPR406

57.89

−0.7

  1. Tau proteins were isolated from AD brain extracts and purified for LC-MS/MS analysis to identify sites of tau phosphorylation and acetylation. The residue number, peptide sequence (bold denotes the modified residue), and significance values are depicted. The tau sequences listed are based on full-length human 2N4R tau (441 residues). The protein confidence score p is represented as −10Log p. Peptide mass accuracy is represented as parts per million (ppm).
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