Table 1 Novel genetic loci exerting genome-wide significant sex-dimorphic or sex-homogeneous effects on FI/FG in individuals without diabetes.
From: Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability
Primary trait | SNP | Chr:Pos | Nearest gene | Alleles (effect/other) | EAF | Analysis | FG effect (SE) | FG P | FG N | FI effect (SE) | FI P | FI N |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
FI | rs7798471 | 7:6744957 | ZNF12 | C/T | 0.273 | Sex-specific (men) | 0.0026 (0.0040) | 0.517 | 43,868 | 0.0067 (0.0051) | 0.182 | 29,394 |
Sex-specific (women) | 0.0063 (0.0036) | 0.082 | 51,424 | 0.0262 (0.0046) | 1.55 × 10−8 | 34,987 | ||||||
Sex-dimorphic | 0.178 | 4.54 × 10−8 | ||||||||||
Sex heterogeneity | 0.493 | 4.6 × 10−3 | ||||||||||
FG | rs11919595 | 3:142617816 | ZBTB38 | T/C | 0.919 | Sex-combined | 0.0248 (0.0043) | 9.75 × 10−9 | 138,567 | −0.0022 (0.0053) | 0.684 | 100,922 |
FG | rs223486 | 4:103684953 | MANBA, UBE2D3 | C/G | 0.507 | Sex-combined | 0.0135 (0.0025) | 3.92 × 10−8 | 91,405 | −0.0002 (0.0029) | 0.954 | 65,353 |
FG | rs1281962 | 6:153431376 | RGS17 | C/G | 0.538 | Sex-combined | 0.0106 (0.0019) | 3.61 × 10−8 | 151,151 | 0.0015 (0.0023) | 0.525 | 104,730 |
FG | rs2785137 | 10:95386207 | PDE6C | G/A | 0.649 | Sex-combined | 0.0117 (0.0021) | 4.97 × 10−8 | 136,750 | −0.0027 (0.0025) | 0.282 | 99,243 |
FG | rs7178572 | 15:77747190 | HMG20A | G/A | 0.688 | Sex-combined | 0.0119 (0.0021) | 2.70 × 10−8 | 138,579 | 0.0020 (0.0025) | 0.443 | 100,920 |
FG | rs6598541 | 15:99271135 | IGF1R | A/G | 0.362 | Sex-combined | 0.0121 (0.0021) | 1.04 × 10−8 | 138,505 | 0.0063 (0.0025) | 0.013 | 100,921 |
FG | rs8044995 | 16:68189340 | NFATC3 | G/A | 0.836 | Sex-combined | 0.0162 (0.0028) | 5.76 × 10−9 | 127,333 | −0.0022 (0.0034) | 0.521 | 90,483 |
