Table 1 Summary of tested AskA, AskB, AskC, MrpC, FruA, and ambruticin VS-3 interactions (including negative controls)^f.

AskA-AskB

y

2.3 ± 0.1

3.0 ± 1

n.d.

2.8 ± 1.0

AskA-AskC

y

4.1 ± 0.1

1.4 ± 0.2

n.d.

2.8 ± 1.4

AskB-AskC

y

0.9 ± 0.4

0.4 ± 0.02

n.d.

0.7 ± 0.3

AskA-MrpC

y

0.5 ± 0.1

1.0 ± 0.04

n.d.

0.8 ± 0.3

AskB-MrpC

y

2.1 ± 0.9

0.3 ± 0.01

n.d.

1.2 ± 1.0

AskC-MrpC

y

1.4 ± 0.6

1.6 ± 0.05

n.d.

1.5 ± 1.0

AskA-FruA

y

1.4 ± 1.0

0.5 ± 0.06

n.d.

1.0 ± 1.0

AskB-FruA

y

2.1 ± 1.3

0.2 ± 0.03

n.d.

1.2 ± 1.0

AskC-FruA

y

1.3 ± 1.0

1.5 ± 0.2

n.d.

1.4 ± 1.0

AskA-MXAN_0727

n

—

—

n.d.

—

AskB-MXAN_0727

n

—

—

n.d.

—

AskC-MXAN_0727

n

—

—

n.d.

—

AskA-BSA

n

—

—

n.d.

—

AskB-BSA

n

—

—

n.d.

—

AskC-BSA

n

—

—

n.d.

—

AskA- ambVS3

n

—

—

n.d.

—

AskB- ambVS3

n

—

—

n.d.

—

AskC- ambVS3

y

159 ± 19

512 ± 128

n.d.

300 ± 200

AskC-myvA

n

—

—

n.d.

—

MrpC-ambVS-3-P_mrpC

y

n.d.

n.d.

<0.005

—

MrpC-ambVS-3

n

—

—

n.d.

—