Table 2 Summary of modelling statistics.

From: Concordant peripheral lipidome signatures in two large clinical studies of Alzheimer’s disease

  

Model

C-statistic 95% CI

Net Reclassification Index (total)

Net Reclassification Index (event)

Diagnosis of AD

Discovery: AIBL

Replication: ADNI

Age + Sex +  BMI + APOE

0.731 (0.726–0.736)

–

–

Age + Sex + BMI + APOE + 10 lipidsa

0.752 (0.747–0.757)

0.40 (0.38 – 0.42)

0.19 (0.17–0.20)

Discovery: ADNI

Replication: AIBL

Age + Sex + BMI + APOE

0.820 (0.817–0.823)

–

–

Age + Sex + BMI + APOE + 10 lipidsb

0.869 (0.866–0.871)

0.84 (0.82–0.85)

0.44 (0.42–0.45)

Future onset of AD

Discovery: AIBL

Replication: ADNI

Age + Sex +  BMI + APOE

0.644 (0.640–0.648)

–

–

Age + Sex + BMI + APOE + 5 lipidsc

0.675 (0.671–0.680)

0.25 (0.23–0.27)

0.05 (0.04–0.07)

Discovery: ADNI

Replication: AIBL

Age + Sex +  BMI + APOE

0.716 (0.709–0.723)

–

–

Age + Sex +  BMI + APOE + 5 lipidsd

0.733 (0.727–0.740)

0.45 (0.41–0.48)

0.17 (0.14–0.21)

  1. aLipid model comprises GM3(d18:1/24:1), PC(O-32:2), PC(15-MHDA_18:1), AC(13:0), PC(P-18:0/22:5), CE(17:0), PC(O-38:5), Cer(d18:2/26:0), PC(P-16:0/18:2) and PC(P-16:0/20:4).
  2. bLipid model comprises PE(O-36:5), SM(d18:2/18:1), PC(O-40:7) (b), SM(43:1), PE(16:0_18:3) (b), CE(24:5), LPC(20:2) [sn1], PS(38:4), GM3(d18:1/20:0) and GM3(d18:1/24:0).
  3. cLipid model comprises DE(18:1), Cer(d18:1/24:1), LPE(18:0) [sn1], Cer(d19:1/24:1) and SM(41:0).
  4. dLipid model comprises DE(18:1), TG(O-52:2) [NL-16:0], PE(16:0_20:3), Cer(d19:1/18:0) and Hex3Cer(d18:1/22:0).
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