Fig. 9: Ethanol inhibits the noradrenergic system at noradrenergic neuron somata or dendritic input but not at the terminals. | Nature Communications

Fig. 9: Ethanol inhibits the noradrenergic system at noradrenergic neuron somata or dendritic input but not at the terminals.

From: Ethanol abolishes vigilance-dependent astroglia network activation in mice by inhibiting norepinephrine release

Fig. 9: Ethanol inhibits the noradrenergic system at noradrenergic neuron somata or dendritic input but not at the terminals.

a Left, scheme of the awake topical pharmacology experimental design. Middle, representative average Ca2+ response trace of BG processes of Aldh1l1-CreERT2;Ai95 mouse. Ethanol bath concentration was 30 mM. Green bars, enforced locomotion. Right, Population data, mean ΔF/F10s ±  SEM of trials 1–3, 5–7, and 9–11, respectively. n = 4 mice; repeated measures ANOVA (F(2, 6) = 0.114) was followed by Tukey–Kramer correction. b as a; however, ethanol was injected (2 g/kg i.p.) and MK912 bath concentration was 15 μM. Population data, mean ΔF/F10s ± SEM of trials 1–3, 5–7, and 9–11, respectively. n = 7 mice; repeated measures ANOVA (F(2, 12) = 14.419) was followed by Tukey–Kramer correction; n.s. not significant. Source data are provided as a Source Data file.

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