Fig. 6: Schematic of the ‘capture’ and ‘lock’ mechanism of 53BP1 foci formation. | Nature Communications

Fig. 6: Schematic of the ‘capture’ and ‘lock’ mechanism of 53BP1 foci formation.

From: Spatiotemporal dynamics of 53BP1 dimer recruitment to a DNA double strand break

Fig. 6

a–d FFS analysis of 53BP1 dynamics in live DIvA cells revealed that upon DSB induction H2AK15ub mediates efficient 53BP1 dimer capture onto a DSB site (a), H4K20me2 serves a lock function for 53BP1 dimer retention at this nuclear location (b), and it is this cooperative interaction with H2AK15ub and H4K20me2, which initiates 53BP1 oligomerization (c) and 53BP1 foci formation (d).

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