Fig. 2: Benchmarking of DLPTP on a synthetic dataset confirms FDR control and high sensitivity. | Nature Communications

Fig. 2: Benchmarking of DLPTP on a synthetic dataset confirms FDR control and high sensitivity.

From: A computational method for detection of ligand-binding proteins from dose range thermal proteome profiles

Fig. 2: Benchmarking of DLPTP on a synthetic dataset confirms FDR control and high sensitivity.

a Observed FDR versus nominal FDR for 3 random seeds for bootstrapping (B = 100) with the standard and moderated DLPTP method applied to a synthetic dataset. b Observed TPR versus observed FDR curves for the standard and moderated DLPTP method and the threshold-based approach. Shown is the average of three different random seeds for both DLPTP methods with 100 bootstraps. Vertical lines correspond to observed FDR at 1, 5, and 10%, x represents results obtained with different DLPTP versions at 1%, + at 5%, and * at 10% nominal FDR. FDR: false discovery rate; TPR: true positive rate.

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