Fig. 3: DLPTP recovers known drug–protein interactions from published datasets. | Nature Communications

Fig. 3: DLPTP recovers known drug–protein interactions from published datasets.

From: A computational method for detection of ligand-binding proteins from dose range thermal proteome profiles

Fig. 3: DLPTP recovers known drug–protein interactions from published datasets.

a Volcano plot for the 2D-TPP dataset acquired upon treatment of HepG2 cells with the HDAC inhibitor panobinostat2. b Analogous to a, for the JQ1 2D-TPP dataset acquired in THP1 lysate23. a, b Blue points represent proteins that were detected as stabilized by the drug treatment and orange as destabilized, at 10% FDR. Axes are outlined in Fig. 1b.

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