Fig. 1: LncRNA identified as PPARα targets are expressed in several oxidative tissues but exhibit liver-specific transcriptional response to WY-14643. | Nature Communications

Fig. 1: LncRNA identified as PPARα targets are expressed in several oxidative tissues but exhibit liver-specific transcriptional response to WY-14643.

From: Long non-coding RNA Gm15441 attenuates hepatic inflammasome activation in response to PPARA agonism and fasting

Fig. 1: LncRNA identified as PPARα targets are expressed in several oxidative tissues but exhibit liver-specific transcriptional response to WY-14643.The alternative text for this image may have been generated using AI.

a Venn diagrams of RefSeq transcripts and lncRNA transcripts that were differentially regulated by WY-14643 (fold change > 2 at FDR < 0.05) in wild-type and in Ppara−/− mouse liver, as determined by RNA-seq. 123 of the RefSeq genes are non-coding, indicated by their NR accession numbers. Six RefSeq genes and six lncRNA genes show opposite responses to WY-14643 treatment and are excluded from the gene counts shown. b Relative basal lncRNA expression in select tissues. c LncRNA expression in tissues from Ppara+/+ and Ppara−/− mice treated with WY-14643 for 48 h. At least five mice were analyzed for each genotype and treatment group. Each bar represents the mean ± SD for n = 5 tissue samples. Adjusted p values, provided in the panels, as determined by ANOVA with Tukey’s multiple comparison correction, one-sided for comparisons to Ppara+/+ mice or as shown (dashed horizontal lines). ND not detected.

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