Fig. 6: Loss of Gm15441 potentiates inflammasome activation during physiological response to acute fasting. | Nature Communications

Fig. 6: Loss of Gm15441 potentiates inflammasome activation during physiological response to acute fasting.

From: Long non-coding RNA Gm15441 attenuates hepatic inflammasome activation in response to PPARA agonism and fasting

Fig. 6: Loss of Gm15441 potentiates inflammasome activation during physiological response to acute fasting.The alternative text for this image may have been generated using AI.

a Physiological endpoints from Gm15441+/+ and Gm15441LSL mice after 24 h fasting. Weight loss and liver indices (mg liver/g body mass; a measure of hepatomegaly), as well as blood ALT, AST, and glucose levels, in response to fasting. b Representative ORO staining of liver tissues after a 24 h fed or fast in Gm15441+/+ and Gm15441LSL mice (n = 5, 3 images/mouse). Scale bars represents 100 nm (×200). c Non-esterified fatty acid (NEFA) from serum, triglycerides (TG) and cholesterol (CHOL) levels from serum and liver tissues after a 24 h fast. d Analysis of Apoa4, Bhmt, Lcn2, Orm2, Saa1, and Saa2 mRNAs in livers of Gm15441+/+ and Gm15441LSL mice after 24 h fasting. Each data bar represents the mean ± SD for n = 5 liver samples; green bars, 24 h fasting. Adjusted p values, provided in the panels, as determined by ANOVA with Tukey’s multiple comparison correction, two-sided for comparisons between fast-stimulated and unstimulated livers of the same genotype, or as shown (dashed horizontal lines).

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