Fig. 5: Top IDAcomboscore predictions for late-stage clinical drugs in CTRPv2.

IDAcomboscores were calculated for all two-drug combinations of late-stage clinical drugs in CTRPv2 using all available cell lines for each drug combination. Darker blue squares represent higher comboscores and, therefore, greater predicted drug combination efficacies relative to the constituent monotherapies. Black boxes represent missing values, where efficacies could not be predicted for a combination. The first bar, farthest left on the right side of the heatmap, indicates whether or not that drug is currently used for cancer treatment, the second bar indicates what stage of clinical trials that drug has reached, and the third bar indicates if the known Csustained concentration for the drug was higher than the maximum tested concentration in CTRPv2 such that predictions had to be made with a lower than clinical concentration. The barplot on top of the heatmap indicates the average viability achieved using that drug as a monotherapy (full bar indicates 100% viability). Drugs that were not predicted to combine well with any other drugs (i.e. with a comboscore < 0.004) were excluded from this plot to improve readability, but a full heatmap with all late-stage clinical drugs can be found in the “IDACombo Paper” project on OSF (see “Methods” section). Colored outlines are used to highlight certain combinations according to the “Combinations of” legend in the bottom right. Source data are provided as a Source Data file.