Fig. 1: Phylogeny of 907 Escherichia coli isolates associated with different clinical phenotypes.

Midpoint-rooted maximum-likelihood phylogenetic tree based on 109,023 variable sites identified in a core genome alignment (1.136 Mbp). Ring 1, 2, and 3 denote predominant sequence types (ST), corresponding clonal complexes (CC), and phylogroup assignment. Clinical phenotypes are labeled according to the key (ring 4). Phylogenetic clusters identified using BAPS (Bayesian analysis of population structure) significantly enriched with invasive UPEC isolates are highlighted in ring 5. The presence of the afaVIII and papGII (blue and red dots) across the phylogeny is annotated in ring 6. The scale bar indicates the number of substitutions per site in the core genome alignment. A tree with bootstrap support values is provided in Supplementary Fig. 20. The tree was visualized using iTOL89. An interactive visualization of this phylogenetic tree can be found out at https://microreact.org/project/O4QAYAJWw.