Fig. 4: Scope of heterodiamination. | Nature Communications

Fig. 4: Scope of heterodiamination.

From: Vicinal difunctionalization of carbon–carbon double bond for the platform synthesis of trifluoroalkyl amines

Fig. 4

1st stage: 1 (0.2–0.3 mmol) added at 0.3 mmol h−1 rate, R1R2NH (1.0 equiv.), MeCN, c = 0.05 M, −20 °C, 0.16 h mmol−1; 2nd stage: R3R4NH or Nu (2.5 equiv.), −20 → 25 °C, 16 h. aAdditional base: 2.5 equiv. 2,6-di-tert-butylpyridine. bAdditional base: 2.5 equiv. NaH. cPotassium phthalimide was used. d2nd stage: 2.6 equiv. R3R4NH, 2.5 equiv. LiHMDS, 2.5 equiv. HMPA, THF, −78 → 25 °C, 16 h.

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