Fig. 2: Binding of 5′ extension of RNA template in nsp13-2. | Nature Communications

Fig. 2: Binding of 5′ extension of RNA template in nsp13-2.

From: Architecture of a SARS-CoV-2 mini replication and transcription complex

Fig. 2: Binding of 5′ extension of RNA template in nsp13-2.The alternative text for this image may have been generated using AI.

a Cutaway view of RNA primer–template pair bound to mini RTC. The structures of nsp7, nsp8, nsp12, and nsp13 are covered by a molecular surface with the same color scheme in Fig. 1. The bound RNA primer–template pair is exhibited as colored cartoons. The missing nucleotides are denoted as a dashed line. b Key interactions nsp13-2 and 5′ extension of RNA template. The molecule of nsp13-2 is shown as a cartoon diagram, and key residues involved in the binding with RNA are shown as colored sticks. The dashed lines indicated the bonds with a distance of less than 3.5 Å.

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