Table 2 sOTUs identified via random forest as important for classifying 1,25(OH)2D, and/or the ratio of activation, ranked by importance score.

From: Vitamin D metabolites and the gut microbiome in older men

Taxa

1,25(OH)2Da

Ratio of activationa

Importance scoreb

P-Firmicutes, C-Clostridia, O-Clostridiales, F-Ruminococcaceae, G-Oscillospira

Negative

Negative

0.0023, 0.0078

P-Firmicutes, C-Clostridia, O-Clostridiales, F-Ruminococcaceae, G-Ruminococcus

Positive

N/A

0.004

P-Firmicutes, C-Clostridia, O-Clostridiales, F-Lachnospiraceae, G-Blautia

Negative

Negative

0.0022, 0.0086

P-Firmicutes, C-Clostridia, O-Clostridiales, F-Lachnospiraceae, G-Coprococcus, S-Catus

Positive

N/A

0.0026

P-Firmicutes, C-Clostridia, O-Clostridiales, F-Lachnospiraceae, G-Blautia, S-Obeum

Positive

N/A

0.0028

P-Firmicutes, C-Clostridia, O-Clostridiales, F-Ruminococcaceae, G-Anaerotruncus

Negative

N/A

0.0022

P-Firmicutes, C-Clostridia, O-Clostridiales, F-Ruminococcaceae

N/A

Positive

0.0155

P-Firmicutes, C-Clostridia, O-Clostridiales, F-Lachnospiraceae

N/A

Positive

0.0146

P-Firmicutes, C-Clostridia, O-Clostridiales, F-Mogibacteriaceae, G-Mogibacterium

N/A

Positive

0.0131

P-Lentisphaerae, C-Lentisphaeria, O-Victivallales, F-Victivallaceae

N/A

Positive

0.0078

P-Firmicutes, C-Clostridia, O-Clostridiale

N/A

Positive

0.0149

P-Firmicutes, C-Clostridia, O-Clostridiales, F-Lachnospiraceae, G-Coprococcus

N/A

Positive

0.0233

  1. aDirection of associations between taxa identified by random forest and each vitamin D metabolite determined by Spearman rank correlation coefficients.
  2. bSignificance of correlation decided by Spearmanʼs p-value with BH-FDR correction.
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