Table 2 Univariable Mendelian randomisation of alcohol consumption and risk of oral and oropharyngeal cancer.
Exposure | Exposure dataset | Exposure N | N SNPs | F-stat | Method | OR | 95% CI | P |
|---|---|---|---|---|---|---|---|---|
Drinks per week☨ | GSCAN | 941,280 | 60 | 74.7 | IVW* | 9.96 | 5.33, 18.6 | 5.64E−13 |
Weighted median | 30.0 | 12.6, 71.5 | 1.47E−14 | |||||
Weighted mode | 40.4 | 15.72, 103.8 | 1.88E−10 | |||||
MR-Egger | 36.7 | 14.1, 95.5 | 6.80E−10 | |||||
MR-PRESSO | 4.50 | 2.26, 8.96 | 7.12E−5 | |||||
GSCAN without UK Biobank*** | 226,223 | 60 | 17.1 | IVW* | 8.25 | 4.74, 14.4 | 8.04E−14 | |
Weighted median | 19.4 | 98.9, 42.1 | 5.09E−14 | |||||
Weighted mode | 17.1 | 7.69, 37.8 | 2.92E−9 | |||||
MR-Egger | 16.4 | 7.47, 36.0 | 3.27E−9 | |||||
MR-PRESSO | NA | NA | NA | |||||
UK Biobank | 414,343 | 60 | 49.0 | IVW* | 5.80 | 3.70, 9.01 | 1.54E−14 | |
Weighted median | 12.4 | 6.79, 22.7 | 3.04E−16 | |||||
Weighted mode | 11.3 | 6.25, 20.4 | 5.09E−11 | |||||
MR-Egger | 9.83 | 5.26, 18.4 | 1.55E−9 | |||||
MR-PRESSO | NA | NA | NA |
