Table 3 Multivariable Mendelian randomisation for smoking initiation and alcohol consumption with risk of oral and oropharyngeal cancer.

From: A multivariable Mendelian randomization analysis investigating smoking and alcohol consumption in oral and oropharyngeal cancer

Exposure

Exposure dataset

N SNPs

Q-stat for instrument strength

F-stat

Q-stat for instrument validity

P-value for instrument validity

Method

OR

95% CI

P

MR analysis using full set of independent SNPs for alcohol and smoking

Comprehensive Smoking Index†

UK Biobank

108

5056

30.1

190.5

0.085

IVW

2.63

1.76, 3.90

1.67E−6

       

MR-Egger

3.24

2.14, 4.92

3.24E−8

 Drinks per week☨

GSCAN without UK Biobank*

60

1141

6.79

  

IVW

5.22

3.16, 8.64

1.16E−10

       

MR-Egger

8.94

4.76, 16.8

8.94E−12

MR analysis without ADH1B

Comprehensive Smoking Index†

UK Biobank

108

3117

18.7

170.9

0.340

IVW

3.14

2.15, 4.58

2.68E−9

       

MR-Egger

3.17

2.13, 4.73

1.43E−8

 Drinks per week☨

GSCAN without UK Biobank*

59

825

4.94

  

IVW

2.07

1.14, 3.76

0.017

       

MR-Egger

2.18

0.87, 5.45

0.094

  1. IVW and MR-Egger regression are two-sided statistical tests.
  2. IVW inverse variance weighted, OR odds ratio, CI confidence intervals, P p-value, Q-stat Cochran’s Q statistic, F-stat conditional F-statistic, *also excludes 23andMe study.
  3. †per SD increase in Comprehensive Smoking Index.
  4. ☨per SD increase in drinks per week.
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