Fig. 3: Primary tumors induce immune tolerance. | Nature Communications

Fig. 3: Primary tumors induce immune tolerance.

From: Single cell analysis reveals distinct immune landscapes in transplant and primary sarcomas that determine response or resistance to immunotherapy

Fig. 3

a Transplant tumors generated by injecting cells from a primary tumor into naive mice or donor mice. b Time to tumor onset in donor (blue) or naive (red) mice. c Survival after αPD-1 and 10 Gy RT. d Cell lines from primary tumors in donor (“self”) or other (“non-self”) mice were injected into donor mice. e Time to tumor onset after self (blue) or non-self (black, dashed) cells injected into donor mice. f Cell lines from amputated primary sarcomas were injected into donor or naive mice after total body irradiation (TBI) followed by bone marrow transplant (BMT). g Time to tumor onset in donor (blue) or naive (red) mice. h Survival after αPD-1 and 20 Gy RT in donor (blue) or naive (red) mice that developed tumors. Survival curves estimated using Kaplan–Meier method; significance determined by log-rank test and Bonferroni correction. Source data are provided as a Source data file.

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