Fig. 6: BDQ exposure leads to metabolite secretion. | Nature Communications

Fig. 6: BDQ exposure leads to metabolite secretion.

From: Bedaquiline reprograms central metabolism to reveal glycolytic vulnerability in Mycobacterium tuberculosis

Fig. 6

The total levels of extracellular and intracellular (a, d) succinate, (b, e) fumarate and (c, f) malate from 13C6 glucose and 13C2 acetate. The extracellular:intracellular ratios for (g) succinate, (h) fumarate and (i) malate. Mean +/− standard error of the mean (SEM) of at least three replicate extracts is indicated. One representative experiment is shown, with the experiment being repeated a minimum of two times. A two-way ANOVA and a Tukey multiple-comparison test were used for the statistical analysis. UT - untreated, BDQ - bedaquiline. n = 4 biologically independent samples. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.

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