Fig. 7: BDQ treatment induces a change in flux directionality. | Nature Communications

Fig. 7: BDQ treatment induces a change in flux directionality.

From: Bedaquiline reprograms central metabolism to reveal glycolytic vulnerability in Mycobacterium tuberculosis

Fig. 7: BDQ treatment induces a change in flux directionality.The alternative text for this image may have been generated using AI.

Metabolic flux maps of (a) untreated and (b) BDQ-treated Mtb growing with glucose as the primary carbon source. The fluxes shown are proportional to the glucose-uptake flux that is arbitrarily set to 100%. The fluxes that are significantly changed in directionality are indicated by red arrows. G6P - glucose 6 phosphate, F6P - fructose-6 phosphate, FBP - fructose-1,6-bisphosphate, GAP - glyceraldehyde-3-phosphate, P5P - pentose 5 phosphate, E4P - erythrose 4 phosphate, S7P - sedoheptulose-7 phosphate, SER - serine, PGA - 3 phosphglyceric acid, PEP - phosphoenolpyruvate, PYR - pyruvate, KIV - 2 ketoisovalerate, VAL - valine, ACCOA - acetyl-CoA, ICIT - isocitrate, OXG - alpha-ketoglutarate, SUCCOA - succinyl CoA, ISOBUTCOA - isobutyrylCoA, SUC - succinate, FUM - fumarate, MALOAA - malate and oxaloacetate, PROPCOA - propionyl-CoA, METCIT - methylcitrate, METICIT - methylisocitrate, ILE - isoleucine, FA - fatty acids.

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