Table 3 Impact of polygenic risk score (PRS) on the breast cancer risk conferred by the PALB2 frameshift mutation.

From: The role of polygenic risk and susceptibility genes in breast cancer over the course of life

 

HR (95% CI)

p value

Lifetime risk, % (95% CI)

Cases

Controls

PALB2 & PRS >90%

11.8 (6.95–20.0)

5.14 × 10−20

83.9 (71.2–96.6)

14

18

PALB2

4.82 (3.77–6.16)

5.66 × 10−36

55.3 (49.4–61.2)

65

211

PRS 10–90%

1.00 (reference)

–

16.0 (15.8–16.2)

5605

81,645

PALB2 & PRS <10%

4.00 (1.66–9.63)

0.002

49.1 (30.6–67.6)

5

23

  1. Population level was defined as women with PRS between the 10th and 90th percentiles. The estimates were obtained from a Cox proportional hazards model on 109,371 women, without adjusting for multiple comparisons. All tests were two-tailed.
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