Fig. 6: Heatmap of expression correlation between N-linked glycosylation enzyme and intact glycopeptides with different glycans. | Nature Communications

Fig. 6: Heatmap of expression correlation between N-linked glycosylation enzyme and intact glycopeptides with different glycans.

From: Glycoproteomics-based signatures for tumor subtyping and clinical outcome prediction of high-grade serous ovarian cancer

Fig. 6: Heatmap of expression correlation between N-linked glycosylation enzyme and intact glycopeptides with different glycans.

a Bi-clustering was performed on correlations between intact glycopeptides (column) and glycosylation enzyme expression in total protein level (row) across 119 tumor samples. Red indicates positive correlation while blue indicates negative correlation. b Boxplot panel of the correlation difference between enzyme expression (protein level) and specific intact glycopeptides. For PRKCSH, n (No) = 128 glycopeptides, n (Yes) = 47 glycopeptides, p = 1.84e-15 (Yes vs. No); For MAN1A1, n (No) = 128 glycopeptides, n (Yes) = 47 glycopeptides, p = 4.93e−17 (Yes vs. No); for FUCA1, n (No) = 97 glycopeptides, n (Yes) = 78 glycopeptides, p = 4.10e−4 (Yes vs. No); for ST3GAL1, n (No) = 117 glycopeptides, n (Yes) = 58 glycopeptides, p = 9.04e−7 (Yes vs. No). Two-tailed unpaired t-test without adjustment is used in b. The box outlines denote the IQR, the solid line in the box denotes median correlation value, and the whiskers outside of the box extend to the minimum and maximum correlation values. Source data are provided as a Source data file.

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