Fig. 6: Circos plot summarizing genome-wide significant associations between 74 cis-pQTLs and 239 traits34 in the inner ring and results from statistical colocalization in the outer ring.
From: Genetic architecture of host proteins involved in SARS-CoV-2 infection
The dashed line in the outer ring indicates a posterior probability of 75% of shared genetic signal between the protein and a phenotypic trait. Protein targets are classified on the basis of their reported relation to SARS-CoV-2 and COVID-19. Each slice contains any cis-pQTLs associated with the target protein annotated and effect estimates were aligned to the protein increasing allele, i.e., bars with a positive –log10 (p-values) indicate positive associations with a trait from the database and vice versa. Clinical traits are grouped by higher-level categories and colored accordingly. GIT = gastrointestinal tract, Misc = Miscellaneous, No coloc. pos. = colocalization for secondary signals was not possible.
