Fig. 3: Δ1w mice display a maladaptive lethal phenotype in contrast to Δ2w mice. | Nature Communications

Fig. 3: Δ1w mice display a maladaptive lethal phenotype in contrast to Δ2w mice.

From: Nuclear numbers in syncytial muscle fibers promote size but limit the development of larger myonuclear domains

Fig. 3: Δ1w mice display a maladaptive lethal phenotype in contrast to Δ2w mice.

a PCA plot from microarray analysis showing the differential clustering of Δ1w, Δ2w, and control samples (TA muscle). Δ1w muscle displayed a more divergent profile from that of Δ2w and control muscle, which appeared more similar. b Heat map of muscle development genes showed more pronounced alterations in Δ1w compared to Δ2w muscle. c Heat map of genes associated with muscle fiber type revealed Δ1w muscle exhibit increased expression of slow fiber type genes (Myh7, Tnnt1, Atp2a2, Sln) and reduced expression of fast fiber type genes (Myh4, Myh1). d Heat map showing increased expression of apoptosis and oxidative stress genes in Δ1w muscle. e Survival curve for Δ1w, Δ2w, and control mice. Δ1w mice began dying prematurely prior to three months of age while Δ2w mice did not. f Images of Δ1w, Δ2w, and control mice showed kyphosis in Δ1w mice, while Δ2w mice looked similar to controls. Data presentation: (a–d) data generated using microarray data performed on TA muscle at P28; n = 3 per group. Scale bar: 2 cm. Source data are provided as a Source Data file.

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