Fig. 5: Integration of snRNA-seq across the lifespan reveals myonuclear population dynamics. | Nature Communications

Fig. 5: Integration of snRNA-seq across the lifespan reveals myonuclear population dynamics.

From: Single-nucleus RNA-seq identifies transcriptional heterogeneity in multinucleated skeletal myofibers

Fig. 5

a Integrated UMAP of snRNA-seq data from postnatal day (P) 10, P21, 5-month, 24-month, and 30-month tibialis anterior muscle. b Proportional composition of nuclear types across the lifespan. Major categories (FAPs, endothelial cells, smooth muscle) include closely-related subpopulations. Myonuclei are combined (top graph) and subsetted (bottom graph) to display myonuclear composition dynamics.

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