Fig. 8: SF1 neurons and their projections to PVT elicit flavor aversion. | Nature Communications

Fig. 8: SF1 neurons and their projections to PVT elicit flavor aversion.

From: An excitatory ventromedial hypothalamus to paraventricular thalamus circuit that suppresses food intake

Fig. 8: SF1 neurons and their projections to PVT elicit flavor aversion.The alternative text for this image may have been generated using AI.

a Mice treated with LiCl via i.p. injections showed aversion to the initially preferred flavor as compared to vehicle-treated SF1-Cre mice (n = 3 males and 3 females per group; post conditioning Saline vs LiCl, p = 0.0002). b–c DREADD activation of VMH SF1 neurons with J60 via i.p. injections induced flavor aversive-like behavior in b hM3Dq-transduced mice (n = 7 males and 7 females, p = 0.0003) but not in c mCherry-transduced control mice (n = 5 males and 5 females). d Simultaneous inactivation of PVT neurons with J60 via i.p. diminished the SF1 aversive effect in SF1 neuron hM3Dq and PVT hM4Di-transduced mice (n = 5 males and 5 females). e, f Activation of PVT neurons with J60 via i.p. injections elicited a flavor aversive effect in PVT neuron e hM3Dq-transduced mice (n = 7 males and 7 females, p < 0.0001) but not in f mCherry-transduced mice (n = 4 males and 4 females). Two-tailed Student’s t-tests for a–f; data represent mean ± s.e.m.; ***p < 0.001; ****p < 0.0001; n.s. not significant.

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