Fig. 3: Hyper-IL-6 enables functional recovery after SCC.
a Representative pictures are showing open field hindlimb movement of mice at 1 and 8 weeks after spinal cord crush (wpc) and treatment, as described in Fig. 2. b–d BMS score of animals as described in (a). Scores were evaluated at 0, 1, 3, 7 days post crush (dpc) and then weekly over 8 weeks after spinal cord injury. Values represent means ± SEM of 6–10 animals per group (PTEN+/+/gfp, n = 7; PTEN+/+/hIL-6, n = 9; PTEN−/−/gfp, n = 6; PTEN−/−/hIL-6, n = 10), showing either the average score of the left and right hind paw (b) or left (c) and right (d) side separately. e BMS subscore of hIL-6 treated PTEN+/+(−) and PTEN−/− mice as described in (a). f Average BMS score of left and right hind paws from mice after SCC and bilateral (left and right hemisphere (l + r)) intracortical injection of AAV2-hIL-6 compared to animals that had received a unilateral injection into the left hemisphere (l) only as presented in (b). Values represent the mean ± SEM of 9 animals per group (l, n = 9; l + r, n = 9). Significances of intergroup differences were evaluated using a two-way analysis of variance (ANOVA) with a Tukey post hoc test (b–d) or two-sided student’s t-test (f). P-values indicate statistical significance; ns = non-significant. Source data are provided as a Source data file.
