Fig. 4: Lateral opening mutants of TodX.
From: Uptake of monoaromatic hydrocarbons during biodegradation by FadL channel-mediated lateral diffusion
Structures of the FadL channels discussed in this study. The lateral openings (delineated by the green surface) are similar in size in the wild-type structures of TodX and CymD and differ only slightly from EcFadL, in that the latter does not have a bulge in S2 like TodX and CymD, but a more pronounced kink in S3. The two TodX mutant channels ΔS2 and ΔS2S3 have much smaller lateral openings, while retaining overall high structural similarity to the wild-type protein.
