Fig. 7: Transcriptome overhaul controlled by TBPL2/TFIIA during oocyte growth.
From: TBPL2/TFIIA complex establishes the maternal transcriptome through oocyte-specific promoter usage
At the beginning of oocyte growth, the transcriptome in primordial and early primary follicles (blue cell) depends on TFIID/TBP (blue complex) transcription from broad promoters (blue line). As TBP protein disappears, Pol II transcription initiation is mediated (red line) only by the oocyte-specific TFIIA/TBPL2 complex (red complex) from sharp promoters. At the growing oocyte stage (red cell) TFIIA/TBPL2 complex is responsible for initiating high levels of Pol II transcription, such as mammalian apparent LTR retrotransposons (MaLR) endogenous retroviral elements (ERV) expression and also the expression of genes of which the gene products survey/limit the stability and/or translatability of transcripts previously deposited by TFIID/TBP-dependent Pol II transcription.
