Fig. 7: Inhibition of HDACs in cultured cells. | Nature Communications

Fig. 7: Inhibition of HDACs in cultured cells.

From: Hydroxamic acid-modified peptide microarrays for profiling isozyme-selective interactions and inhibition of histone deacetylases

Fig. 7: Inhibition of HDACs in cultured cells.The alt text for this image may have been generated using AI.

a Sample Western blots on tubulin acetylation (Ac-α-tubulin) and histone acetylation (H3K27, H3K36) upon 5 h treatment with peptides 1a and 13a at 10 µM concentration, with SAHA as positive control (Ac-α-tubulin: 1 µM; H3K27ac, H3K36ac: 5 µM). See Supplementary Fig. 14 for full blots of all replicates. b Quantification of acetylation, normalized to vinculin loading control, and relative to DMSO (data represent mean ± SD, n = 4 biologically independent samples). Source data are provided as a Source Data file.

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