Fig. 4: ELT-EAE mice are interferon-β resistant. | Nature Communications

Fig. 4: ELT-EAE mice are interferon-β resistant.

From: Early-life-trauma triggers interferon-β resistance and neurodegeneration in a multiple sclerosis model via downregulated β1-adrenergic signaling

Fig. 4: ELT-EAE mice are interferon-β resistant.

a, b Mean clinical EAE scores of control EAE and ELT-EAE male (a) and female (b) mice with or without interferon β (IFNβ) treatment (Male Cont-Vehicle: n = 8, Male Cont-IFNβ: n = 10, Male ELT-Vehicle: n = 5, Male ELT-IFNβ: n = 5, Female Cont-Vehicle: n = 5, Female Cont-IFNβ: n = 7, Female ELT-Vehicle: n = 5, Female ELT-IFNβ: n = 5). Interferon-β was treated from 0 to 10 dpi every other day. All data represent mean ± SEM. Two-tailed Student’s t-test, *P < 0.05. Exact P values for asterisks are derived from AUC (from left to right): a <0.0001, b <0.0001.

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