Fig. 7: IR-61 inhibits inflammation before body weight differences occur. | Nature Communications

Fig. 7: IR-61 inhibits inflammation before body weight differences occur.

From: Improvement of obesity-associated disorders by a small-molecule drug targeting mitochondria of adipose tissue macrophages

Fig. 7: IR-61 inhibits inflammation before body weight differences occur.

Mice were fed with HFD for 12 weeks to induce obesity. a Body weight of mice on NCD or HFD concurrently treated with IR-61 or vehicle control. b, c Expression of the inflammatory cytokines in the epi WAT and liver of NCD-fed and HFD-fed mice treated with IR-61 or the vehicle control. d Plasma concentrations of cytokines in NCD-fed or HFD-fed mice treated preventatively with IR-61 or vehicle control. e, f GTT and ITT on NCD-fed or HFD-fed mice treated with IR-61 or vehicle control for 2 weeks. The AUC was determined for each individual animal for GTT and ITT. Sample sizes are (a) n = 6/6/6/6 mice, (b) Tnf n = 5/5/5/5 mice, Il6 n = 4/4/5/5 mice, Il1b n = 5/5/5/5 mice, (c) Tnf n = 5/5/6/6 mice, Il6 n = 5/5/5/5 mice, Il1b n = 5/5/5/5 mice, (d) n = 5/5/5/5 mice, (e) GTT n = 6/6 mice, ITT n = 6/6 mice, (f) GTT n = 6/6 mice, ITT n = 6/6 mice. Results are presented as the mean ± SEM (*p < 0.05, **p < 0.01, ***p < 0.001; two-way ANOVA with Bonferroni post hoc test (longitudinal data in panels (e, f)) and two-sided Student’s t-test (plot graphs in panels (a–f))). Exact p-values are given in the Source Data file. Source data are provided as a Source Data file.

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