Fig. 8: IR-61 treatment reverses hepatic steatosis. | Nature Communications

Fig. 8: IR-61 treatment reverses hepatic steatosis.

From: Improvement of obesity-associated disorders by a small-molecule drug targeting mitochondria of adipose tissue macrophages

Fig. 8

a Representative microscopic pictures of the livers from the established obesity mice treated with IR-61 or vehicle control. b Total liver weight of the two groups of mice. c Representative images of H&E stained livers in the indicated groups (scale bars, 100 μm). d Liver triglyceride and cholesterol content of the two groups of mice. e mRNA abundance of lipid synthesis genes and lipolysis genes in the livers of mice in each treatment group. Sample sizes are (b) n = 5/5 mice, (c) n = 5/5 mice, (d) n = 5/5 mice, (e) Mcad n = 5/5 mice, Hsl n = 5/5 mice, Atgl n = 5/3 mice. Data are presented as the mean ± SEM (*p < 0.05, **p < 0.01, ***p < 0.001; two-sided Student’s t-test). Exact p-values are given in the Source Data file. Source data are provided as a Source Data file.

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