Fig. 5: SARS-CoV-2 infection alters the expression of lung age-associated genes in vitro.
From: The aging transcriptome and cellular landscape of the human lung in relation to SARS-CoV-2
a–c Volcano plots of differentially expressed genes in A549 cells (a), A549 cells transduced with an ACE2 vector (A549-ACE2) (b), or Calu-3 cells (c). Data are from GSE14750777. Age-associated genes are color-coded. d–f Venn diagrams highlighting the intersections between lung age-associated genes and SARS-CoV-2-regulated genes in A549 cells (d), A549-ACE2 cells (e), or Calu-3 cells (f). Statistical significance of the overlap was assessed by the hypergeometric test. g–i Characteristics of age-associated genes that are affected by SARS-CoV-2 infection in A549 cells (g), A549-ACE2 cells (h), or Calu-3 cells (i), from d–f. Statistical significance of the interaction between the directionality of SARS-CoV-2 regulation (induced or repressed) and the directionality of age-association (increase or decrease with age) was assessed by two-tailed Fisher’s exact test.
