Table 2 Univariate and multivariate Fine-Gray regression in the training cohort.
Variable | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
SHR (95% CI) | P value | SHR (95% CI) | P value | |
Collagen signature | 4.11 (2.58ā6.56) | <0.001 | 2.49 (1.52ā4.08) | <0.001 |
Age | 0.99 (0.98ā1.02) | 0.62 | Ā | Ā |
Sex (Female vs. Male) | 0.87 (0.53ā1.43) | 0.58 | Ā | Ā |
BMI (ā„24ākg/m2 vs. <24ākg/m2) | 1.14 (0.69ā1.89) | 0.61 | Ā | Ā |
CEA (Elevated vs. Normal) | 1.08 (0.67ā1.73) | 0.76 | Ā | Ā |
CA 19-9 (Elevated vs. Normal) | 1.58 (0.98ā2.55) | 0.064 | Ā | Ā |
Tumour location | Ā | 0.56 | Ā | Ā |
Ā Ā Ā Antrum of the stomach | Reference | >0.99 | Ā | Ā |
Ā Ā Ā Body of the stomach | 1.32 (0.80ā2.19) | 0.28 | Ā | Ā |
Ā Ā Ā Cardia of the stomach | 1.07 (0.60ā1.90) | 0.82 | Ā | Ā |
Tumour size (ā„4ācm vs. <4ācm) | 3.32 (1.99ā5.52) | <0.001 | 2.35 (1.37ā4.02) | 0.002 |
Lauren classification (Diffuse or mixed vs. Intestinal) | 1.30 (0.82ā2.07) | 0.27 | Ā | Ā |
Differentiation status | Ā | 0.001 | Ā | 0.12 |
Ā Ā Ā Wellā+āModerate | Reference | >0.99 | Reference | >0.99 |
Ā Ā Ā Poor | 2.35 (1.18ā4.69) | 0.015 | 1.42 (0.66ā3.05) | 0.37 |
Ā Ā Ā Undifferentiated | 3.67 (1.81ā7.47) | <0.001 | 2.12 (0.96ā4.72) | 0.065 |
Lymph node metastasis | Ā | <0.001 | Ā | 0.060 |
Ā Ā Ā N0 | Reference | >0.99 | Reference | >0.99 |
Ā Ā Ā N1 | 3.16 (1.35ā7.44) | 0.008 | 2.47 (1.02ā6.20) | 0.044 |
Ā Ā Ā N2 | 3.32 (1.33ā8.24) | 0.01 | 2.50 (1.01ā6.20) | 0.047 |
Ā Ā Ā N3a | 6.18 (2.67ā14.29) | <0.001 | 3.22 (1.25ā8.31) | 0.016 |
Ā Ā Ā N3b | 9.28 (3.94ā21.87) | <0.001 | 4.43 (1.65ā11.94) | 0.003 |
Chemotherapy (Yes vs. No) | 0.75 (0.46ā1.23) | 0.26 | Ā | Ā |