Fig. 2: Prenatal exposure to bendiocarb impacts CD4 T cell homeostasis, cytokine levels, and dendritic cell counts in cord blood. | Nature Communications

Fig. 2: Prenatal exposure to bendiocarb impacts CD4 T cell homeostasis, cytokine levels, and dendritic cell counts in cord blood.

From: Exposure to pesticides in utero impacts the fetal immune system and response to vaccination in infancy

Fig. 2: Prenatal exposure to bendiocarb impacts CD4 T cell homeostasis, cytokine levels, and dendritic cell counts in cord blood.

a Cord blood non-naive (Supplementary Fig. 1) CD4 T cell frequency in exposed (red, n = 98) and unexposed (blue, n = 68) infants. b Cord blood Treg frequency (CD25highFoxP3+CD127lo) in exposed (red, n = 98) and unexposed (blue, n = 68) infants. c Myeloid (Lin-2–HLA-DR+CD11c+CD123-) and plasmacytoid (Lin-2–HLA-DR+CD11c−CD123+) dendritic cell counts in whole cord blood, in exposed (red, n = 142) and unexposed (blue, n = 96) infants. d Cord blood plasma cytokine levels (unadjusted p values: TNF-RI (p < 0.0001), IL-2 (p < 0.0001), IL-4 (p = 0.037), IL-5 (p < 0.0001), IL-7 (p < 0.0001), MDC (p < 0.0001), TNF-RI (p < 0.0001), IP-10 (p = 0.0009), and MIP-1α (p = 0.01), ran in duplicate) in exposed (red, n = 114) and unexposed (blue, n = 73) infants. Following Bonferroni adjustment for all cytokines and chemokines measured, all associations indicated above remained significant with the exception of IL-4 and MIP-1α. All comparisons were made by Wilcoxon rank-sum test. Bars indicate median with interquartile range. Two-sided p values were calculated for all test statistics.

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