Fig. 8: Genomic evolution of samples from Patient A and I. | Nature Communications

Fig. 8: Genomic evolution of samples from Patient A and I.

From: The molecular make up of smoldering myeloma highlights the evolutionary pathways leading to multiple myeloma

Fig. 8

a CCF plot of patient A showing the emergence of a SOX2 cluster before progression. Patient and sample number indicated on axis. The dotted lines represent the % of the difference in CCF from the angle bisector line, which represents perfect identity between the samples Each color represents one cluster of mutations. b Fish-plot summarizing the clonal evolution in parallel to the paraprotein evolution in patient A. c Phylogeny tree showing branching evolution of patient A. Colors correspond to Fish-plot. Numbers represent the number of additional mutations in each clone CCF = cancer clonal fraction. d CCF plot showing the emergence of a CDKN3 cluster before progression in patient I. Patient and sample number indicated on axis. e Fish-plot summarizing the clonal evolution in parallel to the paraprotein evolution in patient I. f Phylogeny tree showing linear evolution in patient I. Colors correspond to Fish-plot. Numbers represent the number of additional mutations in each clone CCF = cancer clonal fraction.

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