Fig. 6: The co-complex structure of RzmA-Cs R148A with C8-CoA. | Nature Communications

Fig. 6: The co-complex structure of RzmA-Cs R148A with C8-CoA.

From: Engineering and elucidation of the lipoinitiation process in nonribosomal peptide biosynthesis

Fig. 6: The co-complex structure of RzmA-Cs R148A with C8-CoA.The alternative text for this image may have been generated using AI.

a Binding affinity measurement of C8-CoA to RzmA-Cs R148A using ITC. b Overall co-complex structure of R148A with C8-CoA. c Superimposition of R148A in complex with C8-CoA (green) and R148A unliganded (blue) by their N-lobes, highlighting the conformational changes of Cs domains during substrate binding. d The enlarged views of C8-CoA binding site. All the residues in sticks mode show their side chains only, except for the G145 which does not have a side-chain.

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