Table 3 Univariate and multivariate analysis of key determinants for infectious virus shedding.

From: Duration and key determinants of infectious virus shedding in hospitalized patients with coronavirus disease-2019 (COVID-19)

Variable

Positive virus culture (n = 33)

Negative virus culture (n = 79)

Univariate odds ratio (95% CI)

Multivariate odds ratio (95% CI)

Viral RNA load

 >107 RNA copies/mL

29 (87.9%)

22 (27.8%)

18.8 (5.5–64.2), p < 0.001

14.7 (3.7–58.1), p <  0.001

Duration of symptoms

   <7 days

20 (60.6%)

17 (21.5%)

5.6 (1.7–18.1), p  = 0.004

2.1 (0.4–11.7), p  =  0.31

Serum neutralizing antibody titer

 1:20 or higher

6 (18.2%)

75 (94.9%)

0.01 (0.003–0.05), p <  0.001

0.01 (0.002–0.08), p < 0.001

Immunocompromised

 Yes

10 (30.3%)

10 (12.7%)

3.00 (0.8–11.0), p =  0.098

2.0 (0.7–5.3), p  =  0.22

  1. Results of the univariate and multivariate generalized estimating equation analysis. The analyses were limited to the samples for which a viral RNA load and a serum neutralizing antibody titer were available from samples taken at the same day.
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