Fig. 1: Arthritis regulating loci in the DA^Mut rat is restricted to a 2-Mb region on chromosome 9.

a Mean arthritis score after pristane-induced arthritis in 5 DA and 7 DA^Mut rats. The arthritis data has been reproduced three times with the same results. b Incidence of arthritis after pristane-induced arthritis in DA and DA^Mut rats. c LOD score plot for incidence of PIA in 51 (E3.DA-Pia457x DA^Mut) x DA^Mut rats of all genotyped chromosomes. d LOD score plot for incidence of PIA in (E3.DA-Pia457 × DA^Mut) DA^Mut rats on chromosome 9, broken line at 2.63 indicate significant linkage e Schematic figure of the DA^Mut.E3-Pia43 congenic fragment on chromosome 9 with location of the SH3gl1 gene. Microsatellite markers in the Acsbg2 and Uxs1 genes indicate inner border of congenic fragment and markers Mllt1 and Dazl indicate outer borders. f Mean arthritis score after pristane-induced arthritis in 8 DA^Mut and 4 DA^Mut E3-Pia43 heterozygote littermates. Arthritis has been reproduced in several different congenic fragments with the same results. Non-parametrical Mann–Whitney U test was used for statistical evaluation of data. Data are presented as mean with error bars indicating ± SEM with each dot representing an individual value.