Fig. 1: Architecture of hexameric SARS-CoV-2 Nsp15. | Nature Communications

Fig. 1: Architecture of hexameric SARS-CoV-2 Nsp15.

From: Cryo-EM structures of the SARS-CoV-2 endoribonuclease Nsp15 reveal insight into nuclease specificity and dynamics

Fig. 1: Architecture of hexameric SARS-CoV-2 Nsp15.The alternative text for this image may have been generated using AI.

a Domain organization of Nsp15. The numbering corresponds to the amino acid residues at the domain boundaries. The Nsp15 N-terminal domain (ND) is shown in orange, the middle domain (MD) is shown in red, and the poly-U-specific endonuclease domain (endoU) is shown in beige. b Orthogonal views of the cryo-EM map reconstruction of UTP-bound Nsp15 (left) and its corresponding model shown as a cartoon (right). Each Nsp15 protomer is colored as green (P1), purple (P2), coral (P3), tan (P4), gray (P5), and blue (P6). c Model of Nsp15 protomer shown as a cartoon and colored as seen in (a). The position of the Nsp15 endoU active site is highlighted with a black box and the modeled nucleotide is shown as sticks (cyan). N and C mark the N- and C-termini, respectively.

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