Fig. 4: Anticoagulation and the neutralization studies in mice.
From: A DNA origami-based aptamer nanoarray for potent and reversible anticoagulation in hemodialysis
a Mice (n = 5) were treated with buffer (Control), T-16A-H (20 μM, 100 μl) or Aptarray (~560 nM, 100 μl) via a single tail vein injection. Antidotes were administrated intravenously to mice followed by Aptarray for the neutralization study in vivo. Plasma was collected from treated mice and APTT was measured. b Schematic drawing of a murine tail-transection bleeding model. c Mice (n = 5) were treated with buffer (Control), T-16A-H (20 μM, 100 μl) or Aptarray (~560 nM, 100 μl). Antidotes were then administrated intravenously to the anticoagulated animals for neutralization. The tail tips were amputated and the blood loss of mice was measured. Data represent the mean ± s.d. from five (a, c) independent replicates. Statistical significance (a, c) was calculated by one-way ANOVA with the Tukey post hoc test. NS, P > 0.05. Source data are provided as a Source Data file.
