Table 1 Population description for the KB and IGR hospitals and association between variables measured at admission and severity.

Severity: “Intubation” OR “O₂ ≥ 15 L” OR “Death”

30% [817]

–

32% [144]

–

–

Intubation

13% [837]

–

11% [150]

–

–

O₂ ≥ 15 L

15% [837]

–

11% [150]

–

–

Death

17% [837]

–

17% [150]

–

–

Age

63.0 (52.0, 77.0) [833]

1.61 (1.37, 1.90)

7.32 × 10⁻⁰⁹

6.10 (49.0, 71.0) [149]

1.35 (0.92, 1.98)

1.29 × 10⁻⁰¹

2.54 × 10⁻⁰⁹

Yes

Sex

57% [837]

1.97 (1.43, 2.72)

3.03 × 10⁻⁰⁵

49% [150]

1.07 (0.51, 2.23)

8.67 × 10⁻⁰¹

3.52 × 10⁻⁰⁵

Yes

BMI

27.0 (23.5, 31.1) [400]

1.17 (0.95, 1.43)

1.39 × 10⁻⁰¹

24.9 (21.5, 27.7) [108]

1.28 (0.81, 2.00)

2.87 × 10⁻⁰¹

1.00 × 10⁻⁰¹

Height

1.7 (1.6, 1.8) [404]

1.18 (0.96, 1.46)

1.13 × 10⁻⁰¹

1.7 (1.6, 1.8) [109]

1.08 (0.69, 1.71)

7.30 × 10⁻⁰¹

1.05 × 10⁻⁰¹

Weight

75.0 (62.0, 90.0) [543]

1.08 (0.91, 1.29)

3.84 × 10⁻⁰¹

72.0 (60.0, 85.0) [119]

1.31 (0.86, 1.99)

2.06 × 10⁻⁰¹

2.81 × 10⁻⁰¹

Oxygen saturation

95.0 (90.0, 97.0) [783]

0.37 (0.30, 0.45)

6.42 × 10⁻²⁰

97.0 (94.0, 99.0) [132]

0.35 (0.20, 0.63)

4.33 × 10⁻⁰⁴

7.32 × 10⁻²²

Yes

Diastolic pressure

80.0 (69.0, 90.0) [769]

0.70 (0.60, 0.83)

3.93 × 10⁻⁰⁵

78.0 (69.0, 84.8) [138]

0.75 (0.51, 1.11)

1.55 × 10⁻⁰¹

1.74 × 10⁻⁰⁵

Yes

Respiratory rate

25.0 (20.0, 30.0) [667]

1.33 (1.12, 1.58)

1.10 × 10⁻⁰³

22.0 (18.0, 28.0) [67]

3.37 (1.28, 8.86)

1.39 × 10⁻⁰²

2.70 × 10⁻⁰⁴

Yes

Systolic pressure

134.0 (118.0, 148.0) [769]

0.82 (0.70, 0.97)

1.84 × 10⁻⁰²

125.0 (113.5, 137.5) [139]

0.74 (0.50, 1.10)

1.37 × 10⁻⁰¹

9.87 × 10⁻⁰³

Cardiac frequency

95.0 (82.0, 107.0) [771]

0.94 (0.80, 1.10)

4.29 × 10⁻⁰¹

90.0 (80.0, 102.2) [136]

1.27 (0.86, 1.87)

2.33 × 10⁻⁰¹

5.68 × 10⁻⁰¹

Body temperature

37.8 (37.0, 38.5) [788]

0.99 (0.84, 1.17)

9.28 × 10⁻⁰¹

37.3 (36.7, 38.0) [137]

6.09 (0.97, 38.36)

5.44 × 10⁻⁰²

8.07 × 10⁻⁰¹

Dyspnea

68% [837]

1.73 (1.23, 2.45)

1.87 × 10⁻⁰³

57% [150]

1.67 (0.78, 3.59)

1.88 × 10⁻⁰¹

9.93 × 10⁻⁰⁴

Chest pain

8.2% [837]

0.27 (0.12, 0.61)

1.54 × 10⁻⁰³

5.3% [150]

0.78 (0.15, 4.04)

7.68 × 10⁻⁰¹

1.52 × 10⁻⁰³

Myalgia

24% [837]

0.59 (0.41, 0.86)

6.20 × 10⁻⁰³

13% [150]

0.99 (0.32, 3.01)

9.83 × 10⁻⁰¹

6.95 × 10⁻⁰³

Confusion

9.4% [837]

1.73 (1.06, 2.81)

2.80 × 10⁻⁰²

2.7% [150]

7.62 (0.77, 75.63)

8.28 × 10⁻⁰²

1.37 × 10⁻⁰²

Coughing

41% [837]

0.78 (0.57, 1.06)

1.10 × 10⁻⁰¹

31% [150]

0.88 (0.40,1.97)

7.64 × 10⁻⁰¹

1.04 × 10⁻⁰¹

Diarrhea

8.0% [837]

1.30 (0.76, 2.24)

3.42 × 10⁻⁰¹

6.0% [150]

1.20 (0.21, 6.82)

8.39 × 10⁻⁰¹

3.31 × 10⁻⁰¹

Fever

51% [837]

1.11 (0.82, 1.50)

4.98 × 10⁻⁰¹

37% [150]

1.53 (0.71, 3.26)

2.75 × 10⁻⁰¹

3.92 × 10⁻⁰¹

Asthenia

17% [837]

0.78 (0.51, 1.18)

2.41 × 10⁻⁰¹

8.0% [150]

3.18 (0.91, 11.09)

7.01 × 10⁻⁰²

4.01 × 10⁻⁰¹

Symptoms duration before examination

6.0 (3.0, 9.0) [771]

1.02 (0.87, 1.19)

8.13 × 10⁻⁰¹

4.0 (2.0, 7.8) [126]

1.15 (0.78, 1.68)

4.76 × 10⁻⁰¹

7.21 × 10⁻⁰¹

Dry quintuous cough

33% [837]

0.95 (0.69, 1.31)

7.43 × 10⁻⁰¹

20% [150]

1.23 (0.48, 3.17)

6.62 × 10⁻⁰¹

8.05 × 10⁻⁰¹

Headache

5.3% [837]

1.09 (0.57, 2.09)

8.04 × 10⁻⁰¹

3.3% [150]

0.58 (0.06, 5.39)

6.35 × 10⁻⁰¹

8.72 × 10⁻⁰¹

Chronic kidney disease

12% [837]

2.39 (1.54, 3.70)

9.51 × 10⁻⁰⁵

7.3% [150]

16.59 (1.93, 142.84)

1.06 × 10⁻⁰²

1.81 × 10⁻⁰⁵

Yes

Hypertension

45% [837]

1.77 (1.31, 2.40)

2.43 × 10⁻⁰⁴

35% [150]

1.11 (0.51, 2.42)

7.9 × 10⁻⁰¹

2.52 × 10⁻⁰⁴

Yes

Asthma

8.7% [837]

0.41 (0.21, 0.80)

8.87 × 10⁻⁰³

6.0% [150]

0.32 (0.04, 2.71)

2.97 × 10⁻⁰¹

5.81 × 10⁻⁰³

Cardiac disease

22% [837]

1.41 (0.99, 2.02)

5.77 × 10⁻⁰²

17% [150]

1.05 (0.39, 2.78)

9.26 × 10⁻⁰¹

5.94 × 10⁻⁰²

Diabetes

24% [837]

1.32 (0.94, 1.87)

1.13 × 10⁻⁰¹

19% [150]

2.10 (0.83, 5.30)

1.15 × 10⁻⁰¹

6.66 × 10⁻⁰²

Smoker

15% [837]

1.32 (0.87, 2.00)

1.88 × 10⁻⁰¹

25% [150]

2.85 (1.26, 6.44)

1.17 × 10⁻⁰²

8.30 × 10⁻⁰²

Emphysema

6.0% [837]

1.47 (0.80, 2.71)

2.12 × 10⁻⁰¹

14% [150]

4.12 (1.51, 11.25)

5.62 × 10⁻⁰³

8.73 × 10⁻⁰²

Corticosteroids

3.9% [837]

0.61 (0.26, 1.43)

2.57 × 10⁻⁰¹

12% [150]

3.14 (1.05, 9.37)

3.99 × 10⁻⁰²

4.48 × 10⁻⁰¹

Chemotherapy

1.0% [837]

1.39 (0.33, 5.88)

6.50 × 10⁻⁰¹

39% [150]

1.88 (0.89, 3.98)

9.94 × 10⁻⁰²

4.64 × 10⁻⁰¹

Dyslipidemia

16% [837]

1.09 (0.73, 1.65)

6.71 × 10⁻⁰¹

11% [150]

2.67 (0.87, 8.18)

8.65 × 10⁻⁰²

4.74 × 10⁻⁰¹

NSAI

3.6% [837]

1.23 (0.56, 2.68)

6.05 × 10⁻⁰¹

0.7% [150]

0 (0, lnf)

9.88 × 10⁻⁰¹

6.13 × 10⁻⁰¹

Cancer

7.3% [837]

1.17 (0.66, 2.08)

5.87 × 10⁻⁰¹

85% [150]

0.47 (0.17, 1.30)

1.45 × 10⁻⁰¹

7.78 × 10⁻⁰¹

LDH

341.0 (263.5, 452.5) [527]

2.02 (1.63, 2.51)

1.51 × 10⁻¹⁰

278.0 (203.8, 400.0) [134]

2.36 (1.32, 4.21)

3.77 × 10⁻⁰³

9.78 × 10⁻¹²

Yes

Urea

6.0 (4.2, 9.8) [739]

1.66 (1.40, 1.97)

5.72 × 10⁻⁰⁹

5.1 (3.7, 6.9) [117]

2.19 (1.36, 3.52)

1.28 × 10⁻⁰³

3.07 × 10⁻¹⁰

Yes

CRP

69.0 (29.0, 130.0) [729]

1.48 (1.27, 1.74)

1.07 × 10⁻⁰⁶

52.7 (15.1, 115.7) [142]

1.48 (1.03, 2.14)

3.64 × 10⁻⁰²

2.37 × 10⁻⁰⁷

Yes

Neutrophil

5.0 (3.5, 7.1) [746]

1.38 (1.18, 1.62)

8.31 × 10⁻⁰⁵

4.4 (2.3, 7.1) [148]

1.15 (0.80, 1.64)

4.51 × 10⁻⁰¹

6.16 × 10⁻⁰⁵

Yes

Leukocytes

6.7 (4.9, 9.0) [750]

1.31 (1.12, 1.54)

7.18 × 10⁻⁰⁴

6.6 (4.1, 9.8) [144]

1.19 (0.83, 1.71)

3.43 × 10⁻⁰¹

4.73 × 10⁻⁰⁴

Yes

Platelet

206.0 (161.5, 259.5) [751]

0.78 (0.66, 0.93)

5.47 × 10⁻⁰³

213.5 (156.0, 308.0) [144]

0.76 (0.50, 1.15)

1.93 × 10⁻⁰¹

3.06 × 10⁻⁰³

Ferritin

627.0 (287.8, 1285.5) [296]

1.27 (0.99, 1.62)

6.33 × 10⁻⁰²

567.0 (233.0, 1327.0) [125]

1.52 (1.03, 2.26)

3.70 × 10⁻⁰²

2.85 × 10⁻⁰²

Total bilirubin

8.0 (6.0, 11.0) [691]

1.16 (0.99, 1.37)

6.80 × 10⁻⁰²

9.0 (6.0, 13.0) [137]

1.52 (1.04, 2.23)

3.25 × 10⁻⁰²

3.01 × 10⁻⁰²

Conjugated bilirubin

12.0 (9.0, 16.0) [57]

1.32 (0.72, 2.42)

3.63 × 10⁻⁰¹

2.0 (2.0, 5.0) [68]

2.00 (1.10, 3.65)

2.29 × 10⁻⁰²

1.97 × 10⁻⁰¹

Lymphocyte

1.0 (0.7, 1.4) [745]

0.89 (0.70, 1.12)

3.16 × 10⁻⁰¹

1.0 (0.6, 1.6) [148]

0.80 (0.53, 1.21)

2.89 × 10⁻⁰¹

2.42 × 10⁻⁰¹

Monocyte

0.5 (0.3, 0.6) [746]

0.93 (0.79, 1.10)

3.99 × 10⁻⁰¹

0.5 (0.3, 0.8) [148]

0.66 (0.36, 1.19)

1.64 × 10⁻⁰¹

2.84 × 10⁻⁰¹

Hemoglobin

13.2 (12.1, 14.4) [751]

1.06 (0.90, 1.24)

4.84 × 10⁻⁰¹

11.1 (9.5, 12.8) [144]

0.65 (0.43, 0.98)

3.79 × 10⁻⁰²

7.43 × 10⁻⁰¹

Creatine kinase

146.0 (84.0, 312.8) [638]

0.98 (0.82, 1.18)

8.47 × 10⁻⁰¹

70.5 (30.8, 157.2) [92]

1.32 (0.83, 2.10)

2.36 × 10⁻⁰¹

9.88 × 10⁻⁰¹

Disease extent 0/1/2/3/4/5

6.3/17/37/27/11/2.6% [806]

2.43 (2.01, 2.93)

2.13 × 10⁻²⁰

14/36/24/7.2/10/8.7% [138]

1.62 (1.11, 2.37)

1.21 × 10⁻⁰²

1.28 × 10⁻²¹

Yes

Crazy paving

44% [799]

2.72 (1.98, 3.74)

6.48 × 10⁻¹⁰

40% [140]

2.37 (1.10, 5.11)

2.72 × 10⁻⁰²

9.94 × 10⁻¹¹

Yes

Peripheral distribution

63% [749]

0.52 (0.38, 0.72)

7.84 × 10⁻⁰⁵

32% [137]

0.55 (0.23, 1.31)

1.77 × 10⁻⁰¹

3.73 × 10⁻⁰⁵

Yes

Predominance inferior

40% [732]

1.46 (1.06, 2.02)

2.13 × 10⁻⁰²

43% [136]

0.90 (0.42, 1.93)

7.81 × 10⁻⁰¹

2.65 × 10⁻⁰²

GGO

91% [824]

1.72 (0.94, 3.17)

8.02 × 10⁻⁰²

76% [140]

1.55 (0.60, 3.98)

3.66 × 10⁻⁰¹

6.01 × 10⁻⁰²

Consolidation

69% [773]

1.36 (0.95, 1.94)

9.23 × 10⁻⁰²

39% [140]

1.13 (0.53, 2.41)

7.56 × 10⁻⁰¹

8.69 × 10⁻⁰²

GGO rounded

15% [750]

0.64 (0.40, 1.03)

6.63 × 10⁻⁰²

7.5% [107]

3.10 (0.65, 14.75)

1.56 × 10⁻⁰¹

1.18 × 10⁻⁰¹

Consolidation rounded

17& [535]

1.08 (0.66, 1.77)

7.59 × 10⁻⁰¹

18% [55]

0.92 (0.21, 4.09)

9.11 × 10⁻⁰¹

7.77 × 10⁻⁰¹

Cardiomegaly

25% [115]

2.84 (1.19, 6.80)

1.89 × 10⁻⁰²

23% [78]

0.77 (0.22, 2.72)

7.40 × 10⁻⁰¹

2.42 × 10⁻⁰²

Splenomegaly

2.6% [115]

4.11 (0.36, 46.85)

2.55 × 10⁻⁰¹

10% [78]

17.33 (1.88, 160)

1.40 × 10⁻⁰²

1.22 × 10⁻⁰¹

Hepatomegaly

8.7% [115]

1.35 (0.36, 5.12)

6.56 × 10⁻⁰¹

18% [78]

5.17 (1.41, 18.99)

2.02 × 10⁻⁰²

4.00 × 10⁻⁰¹

Corticoid

1.0% [837]

4.7% [150]

Hydroxychloroquine

4.1% [837]

34% [150]

Immunomodulator

2.5% [837]

0% [144]

Kaletra

1.4% [837]

2.0% [150]

Anti-IL6

3.2% [837]

4.7% [150]

Interferon

0.6% [837]

0% [144]