Fig. 1: HFD feeding downregulates T cell mitochondrial function in BAT. | Nature Communications

Fig. 1: HFD feeding downregulates T cell mitochondrial function in BAT.

From: DsbA-L deficiency in T cells promotes diet-induced thermogenesis through suppressing IFN-γ production

Fig. 1: HFD feeding downregulates T cell mitochondrial function in BAT.

a, b Mitochondrial mass of T cells in BAT (a) and iWAT (b) from ND- and HFD-fed mice was analyzed by Mito-Tracker Green staining (n = 4/group). c Gating strategies of mitoSOX-positive and MMPlow T cells in BAT and iWAT. d, e MMP of T cells in BAT (d) and iWAT (e) from ND- and HFD-fed mice was analyzed by Mito-Tracker Green and Mito-Tracker Red staining. (n = 4/group). f, g Mitochondrial ROS of T cells in BAT (f) and iWAT (g) from ND- and HFD-fed mice was analyzed by MitoSOX staining. (n = 4/group). Data shown are representative of three independent experiments. All data are presented as mean ± SEM. Statistical values p < 0.05 (*), p < 0.01 (**), p < 0.001 (***) are determined by two-tailed unpaired Student’s t-test. Source data are provided as a Source Data File.

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