Fig. 5: Late-stage modifications of bioactive or drug molecules.
From: Passerini-type reaction of boronic acids enables α-hydroxyketones synthesis
Reaction conditions: a1a (0.2 mmol, 1 equiv), 2a (0.3 mmol), 3 (0.36 mmol), and CHCl3/pH = 8 buffer (7:3, 1 mL) under an argon atmosphere for 24 hours unless otherwise specified. bThe dr was determined by 1H NMR analysis. c1 (0.2 mmol, 1 equiv), 2a (0.3 mmol), 3 (0.36 mmol) and DCM/pH = 8 buffer (7:3, 1 mL) under an argon atmosphere for 24 hours. dThe dr was determined by HPLC analysis.
