Fig. 3: The fitness comparison of 4 individual mutant viruses against wild-type ZIKV strains in mosquitoes and A129 mice.
From: Role of mutational reversions and fitness restoration in Zika virus spread to the Americas
a-c, The relative fitness of individual mutants in the Dakar strain, tested in mosquito bodies (a), legs (b), and saliva (c). d–f The fitness comparison of individual reversion mutants in the FSS13025 strain, tested in mosquito bodies (d), legs (e), and saliva (f). g, h Each point represents a single mosquito sample. The fitness comparison of DK-V188A (g) and FSS-A188V (h) versus wild-type strains in mouse blood. i, j, The fitness comparison of DK-V188A (i) and FSS-A188V (j) in mosquitoes after oral infection from viremic mice. a–j, The distribution of the model-adjusted means is illustrated by catseye plots with shaded ± standard error (SE) overlaid by scatterplots of individual measures, which are shown on the log (base-10) scale such that comparisons are against a null value of 1. P values are calculated for the group (strain) coefficient for each linear regression model. n numbers represent biologically independent samples and shown on the top of each figure. Source data are provided as a Source Data file. a–f, i, j The results were pooled from 3 independent repeats. g, h The results were collected from a single experiment.
