Fig. 2: Temporal evolutions of spontaneous activities in the single-group 3D neural network model according to the formation of functional connections between neurons. | Nature Communications

Fig. 2: Temporal evolutions of spontaneous activities in the single-group 3D neural network model according to the formation of functional connections between neurons.

From: 3D high-density microelectrode array with optical stimulation and drug delivery for investigating neural circuit dynamics

Fig. 2: Temporal evolutions of spontaneous activities in the single-group 3D neural network model according to the formation of functional connections between neurons.

a Representative spontaneous activities at days in vitro (DIV) 6 and 14: traces of field potential (left) and overlay spike plots (right). b Color-mapped raster plots showing spontaneous activities recorded from 63 electrodes of the 3D multifunctional MEA from DIV 6 to 14. c–j Bar graphs displaying temporal evolutions of spontaneous activities from DIV 6 to 14 (n = 5 independent samples for all data): mean spike rate (c; *P = 0.0102 between DIV 10 and 11), number of active electrodes (d), mean burst rate (e; *P = 0.032 between DIV 10 and 11), burst duration (f), number of spikes in burst (g), inter-spike interval (ISI) in burst activity (h), inter-burst interval (IBI) (i), percentage of burst spikes in total spikes (j). Data are presented as mean values +/− s.e.m. Statistical significance was tested with a two-tailed unpaired t-test. Source Data is available as a Source Data file for Fig. 2b-j.

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