Fig. 2: Engineering ligand-binding domains creates opportunities for translating the biosensing of target molecules into digital signals. | Nature Communications

Fig. 2: Engineering ligand-binding domains creates opportunities for translating the biosensing of target molecules into digital signals.

From: Sensing the future of bio-informational engineering

Fig. 2

(A) Pyrroloquinoline quinone glucose dehydrogenase (GDH) releases an electron in the presence of glucose, which can be detected using an electrode in a blood-glucose monitor. (B) Split GDH fused to ligand-binding domains (LBDs) for another molecule can be used as a generic biosensor, as the GDH domains can only co-localize to release an electron when the fused LBDs bind to a molecule of interest.

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