Fig. 6: Model for the role of RPA-binding in specifically recruiting the BTR complex to stalled replication forks. | Nature Communications

Fig. 6: Model for the role of RPA-binding in specifically recruiting the BTR complex to stalled replication forks.

From: The Bloom syndrome complex senses RPA-coated single-stranded DNA to restart stalled replication forks

Fig. 6

a During normal DNA replication, the BTR complex is not recruited to ongoing replication forks because not enough RPA-coated ssDNA complexes are present. b When a replication fork stalls, increased RPA-ssDNA leads to stable recruitment of the BTR complex and replication fork restart. Gray spheres represent the three RPA-binding motifs in BLM and RMI1.

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