Fig. 3: Chromatin organization at the AICDA locus.

a Normalized Hi-C contact map of the domain structure surrounding the AICDA gene (chr12:8,598,290-8,615,591, GRCh38) in NBC. The log fold change interaction between GCBC, MBC, or PC as compared to NBC was computed. Below each interaction map, chromatin state tracks of three biological replicates per B cell subpopulation are shown. The coordinates of the represented region are chr12:8,550,000–9,050,000, GRCh38. b Multi-layer epigenomic characterization of the AICDA gene region in four B cell subpopulations. Arc diagrams indicate significant Hi-C interactions (continuous red lines involve the region of interest, while dashed red lines involve other regions of chromosome 12). Below them, compartment definition (red, compartment A-type: green, compartment I-type), chromatin states, chromatin accessibility (ATAC-seq, y-axis signal from 0 to 105), and gene expression (RNA-seq, y-axis signal from 0 to 4 for the positive strand and from 0 to −0.1 for the negative strand) are shown. Tracks of Hi-C interactions and compartment definition are based on merged replicates whereas chromatin states, chromatin accessibility, and gene expression tracks of each replicate are shown separately. The coordinates of the represented region are chr12:8,570,000–8,670,000, GRCh38.